Publikationen
1. Mentz, P., Mest, H.-J., Förster, W.
Zur Frage einer unterschiedlichen Resorption von Kardenoliden mit Aldehyd- und Karbinolstruktur
Wiss. Beitr. Martin-Luther-Univ. Halle-Wittenberg, 96-100 (1970)
2. Mest, H.-J., Förster, W.
Digitalis und Herzinfarkt
II. Gemeinsames Symposium d. Inst. für Kardiologie von Armenien u. d. Inst. für Pharmakologie u. Toxikologie
MLU Halle-Wittenberg, Jerewan 1971, 205-209 (1974)
3. Mest, H.-J., Schrör, K., Förster, W.
Antiarrhythmic properties of PGE2: Preliminary results
Adv. Biosci. 9, 385-393 (1973)
4. Förster, W., Mest, H.-J., Mentz, P.
The influence of PGF2a on experimental arrhythmias
Prostaglandins 3, 895-904 (1973)
5. Mest, H.-J., Förster, W.
Evidence for antiarrhythmic efficiency of arachidonic and linoleic acid: Preliminary results
Prostaglandins 4, 751-753 (1973)
6. Mest, H.-J., Mentz, P., Förster, W.
Effects of prostaglandins on experimental arrhythmias
Pol. J. Pharmacol. Pharm. 26, 151-158 (1974)
7. Zehl, U., Mest, H.-J.
Wirkung von Prostaglandinen und Prostaglandin-Präkursoren auf die Arrhythmiegefährdung und Bedeutung der ungesättigten Fettsäuren für den Herzinfarkt
In: Studie zur Bedeutung der Prostaglandine für die Medizin, speziell für die Grundlagenforschung auf dem Gebiet der Herz-Kreislauf- Krankheiten.
FV Herz-Kreislauf-Krankheiten, Berlin, 95-106 (1974)
8. Förster, W., Mest, H.-J., Mentz, P., Bayer, B.-L.
Pharmacological investigations on the antiarrhythmic action of prostaglandins and prostaglandin precursors
2nd Congr. Hung. Pharmacol. Soc., Budapest, 9-13 (1974)
9. Taube, Ch., Förster, W., Block, H.-U., Mest, H.-J.
Antihypertensive drugs and synthesis of prostaglandins in rabbit kidney medulla
2nd Congr. Hung. Pharmacol. Soc., Budapest, 45-48 (1974)
10. Mest, H.-J., Förster, W.
Vergleich der antiarrhythmischen Wirkungen von PGA1, PGA2, PGE1, PGE2 und PGF2a im BaCl-Arrhythmie-Modell des wachen Kaninchens
Arch. Int. Pharmacodyn. Ther. 217, 152-161 (1975)
11. Mest, H.-J., Mentz, P., Förster, W.
Über die antiarrhythmische Wirksamkeit der Prostaglandin- präkursoren Linol- und Arachidonsäure
Abhandl. Akad. Wiss. DDR, Berlin, 69-72 (1975)
12. Block, H.-U., Taube, Ch., Mest, H.-J., Förster, W.
Über den Einfluß blutdruckwirksamer Substanzen auf die Prosta- glandinsynthese im Kaninchennierenmark
Abhandl. Akad. Wiss. DDR, Berlin, 83-88 (1975)
13. Taube, Ch., Mest, H.-J., Block, H.-U., Förster, W.
Akute Prostaglandin E-Veränderungen im Nierenmark nach intra- venöser Gabe blutdruckwirksamer Pharmaka am Kaninchen
Acta biol. med. germ. 34, 1057-1064 (1975)
14. Fiehring, H., Hackenberger, F., von Knorre, G.H., Mann, D., Mest, H.-J., Nelius, D., Parsi, R.A., Schaedel, H.
Empfehlungen für die Therapie von Herzrhythmusstörungen
Zentrale Therapieempfehlungen, 5. Lieferung, Hrsg.: Inst. für Arzneimittelwesen d. DDR, Berlin, 1-26 (1975)
15. Terhaag, B., Förster, W., Mest, H.-J., Schrör, K.
Über antiarrhythmische, kreislaufdynamische und toxische Wirkungen von 4-(3-Diäthylamino-2-hydroxypropyl)-ajmalin (53/12) im Vergleich mit Ajmalin und Propranolol
Pharmazie 31, 39-44 (1976)
16. Förster, W., Mentz, P., Blass, K.-E., Mest, H.-J.
Antiarrhythmic effects of arachidonic, linoleic, linolenic and oleic acid and the influence of indomethacin and polyphloretinphosphate
Adv. Prostaglandin Thromboxane Res. 1, 433-438 (1976)
17. Mest, H.-J., Blass, K.-E., Förster, W.
Über die antiarrhythmische Wirkung der Prostaglandine A1, A2, E1, E2 und F2a am Strophanthin-Arrhythmiemodell der Katze
Acta biol. med. germ. 35, 63-67 (1976)
18. Taube Ch., Mest, H.-J., Block, H.-U., Förster, W.
Changes in prostaglandin synthesis in rabbit kidney medulla after repeated intravenous administration of antihypertensive drugs
Artery 2, 564-573 (1976)
19. Mest, H.-J., Taube, Ch., Förster, W.
Influence of electrically induced and aconitine induced arrhythmias on the prostaglandin (PG) efflux of coronary sinus blood in dogs
J. Mol. Cell. Cardiol., Suppl. 9, 31 (1977)
20. Mest, H.-J., Blass, K.-E., Förster, W.
Effects of arachidonic, linoleic, linolenic and oleic acid on experimental arrhythmias in cats, rabbits and guinea-pigs
Prostaglandins 14, 163-172 (1977)
21. Mest, H.-J., Winkler, J., Förster, W.
The antiarrhythmic effect of PGE2 on catecholamine-induced arrhythmias
Acta biol. med. germ. 36, 1193-1196 (1977)
22. Mest, H.-J., Taube, Ch., Förster, W.
Influence of electrically and aconitine-induced arrhythmias on the prostaglandin efflux in coronary sinus blood in dogs
Acta biol. med. germ. 37, 825-826 (1978)
23. Mest, H.-J., Förster, W.
The antiarrhythmic action of prostacyclin (PGI2) on aconitine- induced arrhythmias in rats
Acta biol. med. germ. 37, 827-828 (1978)
24. Nilius, B., Mest, H.-J.
The influence of the prostaglandin E2 and F2a on electrotropic and inotropic vagel effects on the isolated rabbit atrium
Acta biol. med. germ. 38, 627-633 (1979)
25. Mest, H.-J., Förster, W.
The central nervous effect of prostaglandins I2, E2 and F2a on aconitine-induced cardiac arrhythmias in rats
Prostaglandins 18, 235-239 (1979)
26. Mest, H.-J., Mentz, P., Bayer, B.-L., Zehl, U., Weiss, M., Blass, K.- E., Förster, W.
Influence of prostaglandins on arrhytmias and coronary regulation
Cor et Vasa : myocardial diseases and peripheral circulation disorders, Warszawa, 69-77 (1980)
27. Krause, E.-G., Mest, H.-J., Taube, Ch., Förster, W.
Electrically induced tachyarrhythmia (TX) and the effect of propranolol (prop) on the release of cyclic AMP and PGE by the canince left ventricle
J. Mol. Cell. Cardiol. 12, 81 (1980)
28. Mest, H.-J., Taube, Ch., Förster, W.
Influence of aconitine and ouabain-induced cardiac arrhythmias on the PG-efflux in the canine coronary sinus blood and the influence of antiarrhythmic drugs
In: Prostaglandins and Thromboxanes in the Cardiovascular System and in Gynaecology and Obstetrics
Ed. W. Förster,Fischer Verlag Jena, 103-105 (1981)
29. Mest, H.-J., Hoffmann, P., Förster, W.
Influence of cumulative doses of aconitine or epinephrine on cardiac rhythm in rats fed diets with different contents of linoleic acid
In: Prostaglandins and Thromboxanes in the Cardiovascular System and in Gynaecology and Obstetrics,
Ed. W. Förster, Fischer Verlag Jena, 97-98 (1981)
30. Mest, H.-J., Krause, E.-G., Taube, Ch., Förster, W.
Influence of electrically induced tachyarrhythmia on the release of cyclic AMP and PGE in canine coronary sinus blood and on the level of cyclic AMP in myocardial tissue
In: Prostaglandins and Thromboxanes in the Cardiovascular System and in Gynaecology and Obstetrics
Ed. W. Förster, Fischer Verlag Jena, 99-101 (1981)
31. Mest, H.-J., Singer, P., Sziegoleit, W., Stepanauskas, M., Werner, U., Philipp, G., Klee, W., Heinemann, L., Förster, W., Heine, H.
Determination of levels of 13,14-dihydro-15-keto-PGF2a, PGE2a a fatty acid pattern in peripheral venous plasma of patients with peripheral arterial disease (PAD) with and without diabetes mellitus
In: Prostaglandins and Thromboxanes in the Cardiovascular System
and in Gynaecology and Obstetrics
Ed. W. Förster, Fischer Verlag Jena, 71-73 (1981)
32. Mest, H.-J., Krause, E.-G., Taube, Ch., Förster, W.
Influence of electrically induced tachyarrhythmia on the
release of cyclic AMP and PGE in canine coronary sinus
blood and on the level of cyclic AMP in myocardial tissue
Prostaglandins 21, 623-635 (1981)
33. Mest, H.-J., Taube, Ch., Förster, W., Metsä-Ketelä, T.,
Vapaatalo, H.
Influence of cardiac rhythm disturbances and antiarrhythmic
drugs on the efflux of PGE, PGF2a, cyclic AMP and cyclic
GMP in canine coronary sinus blood
Prostaglandins Med. 7, 1-13 (1981)
34. Mest, H.-J., Förster, W.
Is PGI2 arrhythmogenic?: Investigations on ouabain induced
arrhythmias in cats
Prostaglandins Med. 7, 411-420 (1981)
35. Mest, H.-J.
Untersuchungen zur pathophysiologischen und
pharmakologischen Bedeutung der Prostaglandine bei
tierexperimentellen Herzarrhythmien
Wiss. Z. Martin-Luther-Univ. Halle-Wittenberg, 30,
141-142 (1981)
141-142 (1981)
36. Mest, H.-J.
Untersuchungen zur pathophysiologischen und
pharmakologischen Bedeutung der Prostaglandine bei
tierexperimentellen Herzarrhythmien
Deutsch. Ges.wesen 36, 1280 (1981)
37. Beitz, J., Mest, H.-J., Förster, W.
Influence of linseed oil diet on the pattern of serum
lipide in man
Acta biol. med. germ. 40, K 31-K 35 (1981)
38. Honigmann, G., Schimke, E., Beitz, J., Mest, H.-J.,
Schliak,V.
Influence of diet rich linolenic acid on lipids, fatty acid
pattern of lipids, thrombocytoaggregation and
prostaglandins in type I (insulin-dependent) diabetes
Diabetologia 23, 175 (1981)
39. Krause, E.-G., Mest, H.-J., Taube, Ch., Förster, W.
Electrically induced tachyarrhythmia (TA) and the effect of
propranolol on the release of cyclic AMP and
prostaglandin E by the canine left ventricle
Advances in Cyclic Nucleotide Research, Vol. 14, eds.
Dumont, J.E., Greengard, P. and Robison, G.A., Raven Press,
New York, 690 (1981)
40. Mest, H.-J., Förster, W.
Influence of 15-keto-metabolites and 13,14-dihydro-15-keto-
metabolites of PGE2 and PGF2a as well as 6-keto-PGF1a as a
metabolite of PGI2 on aconitine induced cardiac arrhythmia
in rats
Acta biol. med. germ. 41, 819-822 (1982)
41. Mest, H.-J., Zehl, U., Sziegoleit, W., Taube, Ch.,
Förster, W.
Influence of mental stress on plasma level of
prostaglandins and thromboxane B2 and on circulating
platelet aggregates in man
Prostaglandins Leukotrienes Med. 8, 553-563 (1982)
42. Mest, H.-J., Sziegoleit, W., Förster, W.
Effect of stress exposures on prostaglandin concentration
in the blood plasma of students during examinations
Farmakologija i Toksikologija, 45, 110-112 (1982)
43. Beitz, J., Fischer, S., Hora, C., Honigmann, G.,
Schimke, E., Mest, H.-J., Förster, W.
Influence of linseed or olive oil diet on the action of
lipoproteins (LP) from hyperlipidemic (Type IIa and IV) men
on the prostaglandin I2 (PGI2) formation
4th Dresden Lipid Symposium, International Symposium on
Lipoproteins and Atherosclerosis, Dresden, Vol. 1, 180-183
(1982)
44. Honigmann, G., Schimke, E., Hildebrandt, R., Beitz, J.,
Mest, H.-J., Schulze, B., Schliack, V.
Das Fettsäuremuster der Triglyzeride, Cholesterolester und
Phospholipide bei Diabetes mellitus Typ I vor und nach
linolsäurereicher Diät
4th Dresden Lipid Symposium, International Symposium on
Lipoproteins and Atherosclerosis, Dresden, Vol. 1, 189-193
(1982)
45. Mest, H.-J., Beitz, J., Heinroth, I., Block, H.-U.,
Förster,W.
The influence of linseed oil diet on fatty acid pattern in
phospholipids, on prostaglandin plasma level and
thromboxane formation in platelets in man
4th Dresden Lipid Symposium, International Symposium on
Lipoproteins and Atherosclerosis, Dresden, Vol. 1, 194-197
(1982)
46. Beitz, J., Schimke, E., Honigmann, E., Mest, H.-J.,
Förster,W.
In diabetics linseed oil diet does not change the influence
of lipoproteins (LP) on the prostaglandin I2 (PGI2)
formation
4th Dresden Lipid Symposium, International Symposium on
Lipoproteins and Atherosclerosis, Dresden, Vol. 1, 222-225
(1982)
47. Mest, H.-J., Förster, W.
Influence of PGI2 and PG metabolites on experimental
cardiac arrhythmias
V. International Conference of Prostaglandins, Abstracts
book, Florence (Italy), 280 (1982)
48. Mest, H.-J., Beitz, J., Heinroth, I., Block, H.-U.,
Förster,W.
The influence of linseed oil diet on fatty acid pattern in
phospholipids and on thromboxane formation in platelets in
man
Klin. Wochenschr. 61, 187-191 (1983)
49. Beitz, J., Schimke, E., Honigmann, G., Mest, H.-J.,
Förster,W.
Wirksamkeit der Lipoproteine (LP) von Diabetikern (D) vor
und nach Leinöldiät auf die PGI2-Bildung (PGI2-B.)
Zent.bl. Pharm. 122, 124 (1983)
50. Krause, E.-G., Lehmann, I., Mest, H.-J., Taube, Ch.,
Förster,W.
Electrically induced tachyarrhythmia and the effect of
propranolol on the release of cyclic AMP and
prostaglandin E by the canine left ventricle
Adv. Myocardiol. 4, 185-191 (1983)
51. Mest, H.-J., Rausch, J.
The antiarrhythmic effect of PGE2 on premature ventricular
beats in man
Prostaglandins Leukotrienes Med. 10, 279-288 (1983)
52. Mest, H.-J., Teichmann, W.
Behandlung tachykarder Herzrhythmusstörungen bei ambulanten
Patienten
Recipe, H. 3, 1-3 (1983)
53. Mest, H.-J., Winkler, J.
Significance of sympathetic nervous system for the central
antiarrhythmic effect of prostaglandin E2, F2a and I2 on
aconitine induced cardiac arrhythmias in rats
Biomed. Biochim. Acta 43, 143-146 (1984)
54. Schimke, E., Hildebrandt, E., Beitz, J., Schimke, I.,
Semmler, S., Honigmann, G., Mest, H.-J., Schliack, V.
Influence of a cod liver oil diet in diabetics type I on
fatty acid patterns and platelet aggregation
Biomed. Biochim. Acta 43, 351-353 (1984)
55. Zehl, U., Mest, H.-J., Förster, W.
Influence of aspirin, molsidomine, trapidil and some
trapidil derivatives on arachidonic acid induced reversible
thrombocyte aggregation in the rabbit
Biomed. Biochim. Acta 43, 381-384 (1984)
56. Block, H.-U., Sziegoleit, W., Mest, H.-J.
Estimation of thromboxane B2 in the clotting human whole
blood by gas chromatography
Biomed. Biochim. Acta 43, 385-388 (1984)
57. Heinroth, I., Block, H.-U., Mest, H.-J.
Influence of trapidil derivatives on arachidonic acid and
prostaglandin endoperoxide analogue-induced platelet
aggregation and thromboxane A2 formation
Biomed. Biochim. Acta 43, 389-392 (1984)
58. Hoffmann, W., Förster, W., Mest, H.-J., Taube, Ch.,
Block, H.-U., Braun, H.
Reduced side effects by low dose of acetylsalicylic acid
(ASA)in patients with myocardial infarction; estimations of
serum thromboxane B2 and PGF2a
Biomed. Biochim. Acta 43, 467-470 (1984)
59. Mest, H.-J.
Trapidil (Rocornal) in acute myocardial infarction
CVD Epidemiol. Newsletters 36, 73 (1984)
60. Hoffmann, P., Mest, H.-J.
Pathomechanismus von Herz-Kreislauf-Erkrankungen
Med. aktuell 11, 214-215 (1985)
61. Mest, H.-J.
Gegenwärtiger Stand der Anwendung von Prostaglandinen in
der Klinik
Z. Klin. Med. 40, 1717-1721 (1985)
62. Schimke, E., Hildebrandt, R., Beitz, J., Schimke, J.,
Beitz, A., Semmler, S., Honigmann, G., Mest, H.-J.,
Schliack, V.
Beeinflussung der Fettsäuremuster, Prostaglandine und
Thrombozytenfunktion durch Lebertrandiät bei Typ I-
Diabetikern
Advances in Lipoprotein and Atherosclerosis Research,
Diagnostics and Treatment: Proceedings of the 5th
International Dresden Lipid Symposium, Vol. II, 643-646
(1985)
63. Panse, M., Block, H.-U., Förster, W., Mest, H.-J.
An improved malondialdehyde assay for estimation of throm-
boxane synthase activity in washed human blood platelets
Prostaglandins 30, 1031-1040 (1985)
64. Krause E.-G., Tenor, H., Bartel, S., Mest, H.-J.
Inhibition of cAMP-Phosphodiesterase from heart and
coronary arteries by a new trapidil derivative
Proc. 4th Congr. Hung. Pharmacol. Soc., eds. Szekeres, L.
and J. Gy. Papp, Vol 1, Budapest, 139-142 (1985)
65. Singer, P., Wirth, M., Mest, H.-J., Taube, Ch., Richter-
Heinrich, E., Gödicke, W., Hartrodt, W., Naumann, E.,
Voigt,S.
Änderungen von Blutdruck und Serumlipiden unter Fischdiäten
bei Patienten mit milder essentieller Hypertonie
Z. gesamte inn. Med. 41, 38-44 (1986)
66. Mest, H.-J., Beitz, J.
Bedeutung der Eikosanoide für die Arteriosklerose und der
Einfluß von Lipoproteinen auf die Prostanoid-Bildung
Z. gesamte inn. Med. 41, 94-98 (1986)
67. Mest, H.-J., Thomas, E.
Gibt es eine Renaissance für Trapidil?
Z. gesamte inn. Med. 41, 217-220 (1986)
68. Beitz, J., Block, H.-U., Beitz, A., Müller, G.,
Winkler, L., Dargel, R.T., Mest, H.-J.
Endogenous lipoproteins modify the thromboxane formation
capacity of platelets
Atherosclerosis 60, 95-96 (1986)
69. Beitz, J., Schimke, E., Liebaug, U., Block, H.-U.,
Beitz, A., Honigmann, G., Sziegoleit, W., Müller, G.,
Mest, H.-J.
Influence of a cod liver oil diet in healthy and insulin-
dependent diabetic volunteers on fatty acid pattern, inhi-
bition of prostacyclin formation by low density lipoprotein
(LDL) and platelet thromboxane
Klin. Wochenschr. 64, 793-799 (1986)
70. Singer, P., Berger, J., Lück, K., Taube, Ch., Mest, H.-J.,
Naumann, E., Gödicke, W.
Verhalten von Blutdruck, Serumlipide und Thromboxan B2
unter kurz- und langfristiger Diät mit unterschiedlicher
Dosis von Eikosapentaensäure bei Patienten mit essentieller
Hypertonie
Z. Klin. Med. 41, 1363-1366 (1986)
71. Beitz, J., Mest, H.-J.
Thromboxane A2 (TXA2) formation by washed human platelets
under the influence of low and high density lipoproteins
from healthy donors
Prostaglandins Leukotrienes Med. 23, 303-309 (1986)
72. Hoffmann, W., Förster, W., Mest, H.-J.
Two-year study on the prevention of reinfarction following
the administration of 30 - 60 mg/d acetylsalicylic acid
(ASA) compared to 1000 mg/d ASA
CVD Epidemiol. Newsletters 40, 111 (1986)
73. Mest, H.-J.
Therapeutic possibilities of prostaglandins
Therapeutic possibilities of prostaglandins
Wiss. Z. Martin-Luther-Univ. Halle-Wittenberg, 5,
111-112 (1986)
74. Beitz, J., Honigmann, G., Schimke, E., Müller, G., Mest,
H.-J., Förster, W.
Influence of lipoproteins of healthy and diabetic donors on
the prostacyclin formation in vitro
Wiss. Z. Martin-Luther-Univ. Halle-Wittenberg, 35,
146-148 (1986)
75. Rebmann, U., Fahr, A., Wachsmuth, C., Sziegoleit, W., Schabel, J., Heynemann, H., Pauer, H.D., Mest, H.-J., Langkopf, B., Förster, W.
Effects of iloprost on aggregation behavior in kidney conditioning and changes in iloprost concentration in kidney preservation
Zeitschrift für Urologie und Nephrologie 79 (12) 722-8 (1986)
76. Mest, H.-J.
Bedeutung der Eikosanoide für die Myokardprotektion
Z. Klin. Med. 42, 103-104 (1987)
77. Pönicke, K., Sperling, J., Mest, H.-J.
Endpunktbestimmung bei der Präparation plättchenreicher
Plasmen
Z. med. Lab.diagn. 28, 162-164 (1987)
78. Taube, Ch., Steinborn, Ch., Mest, H.-J.
Zur Wirkung von Trapidil und Trapidilderivat AR 12463 auf
Blutdruck und Thromboxanbildung spontanhypertoner Ratten
Pharmazie 42, 334-336 (1987)
79. Mest, H.-J., Pönicke, K.
Die Bedeutung der Eicosanoide für Hypoxie und Ischämie
Z. Klin. Med. 42, 1037-1040 (1987)
80. Riedel, A., Mest, H.-J.
The effect of PAF (platelet-activating factor) on experi-
mental cardiac arrhythmias and its inhibition by substances
influencing arachidonic acid metabolities
Prostaglandins Leukotrienes Med. 28, 103-109 (1987)
81. Giessler, Ch., Fahr, A., Tertov, V.V., Kudryashov, S.A.,
Orekhov, A.N., Smirnov, V.N., Mest, H.-J.
Trapidil derivatives as potential antiatherosclerotic drugs
Arzneimittelforsch./Drug Res. 37, 538-541(1987)
82. Beitz, J., Schneider, S., Riedel, A., Mest, H.-J.
Do endogenous lipoproteins modulate the sensibility of
animals against arrhythmogenic drugs?
Prostaglandins Leukotrienes Med. 28, 215-220 (1987)
83. Taube, Ch., Steinborn, Ch., Mest, H.-J.
Trapidil derivative AR 12463 lowers blood pressure and
thromboxane formation in spontaneously hypertensive rats
In: Prostaglandins in clinical research, ed. H. Sinzinger,
K. Schrör, New York, Liss, 107-111 (1987)
K. Schrör, New York, Liss, 107-111 (1987)
84. Block, H.-U., Sziegoleit, W., Müller, G., Mest, H.-J.
Experimental variables affecting thromboxan B2 formation in
human whole blood
In: Prostaglandins in clinical research, ed. H. Sinzinger,
K. Schrör, New York, Liss, 149-154 (1987)
K. Schrör, New York, Liss, 149-154 (1987)
85. Mest, H.-J., Riedel, A., Schneider, S.
Relevance of thromboxane-prostacyclin balance for cardiac
rhythm disturbance
In: Prostaglandins in clinical research, ed. H. Sinzinger,
K. Schrör, New York, Liss, 185-190 (1987)
K. Schrör, New York, Liss, 185-190 (1987)
86. Pönicke, K., Sternitzky, R., Mest, H.-J.
Influence of hypoxia on spontaneous aggregation and TXA2-
formation of human blood platelets
In: Prostaglandins in clinical research, ed. H. Sinzinger,
K. Schrör, New York, Liss, 235-240 (1987)
K. Schrör, New York, Liss, 235-240 (1987)
87. Riedel, A., Schneider, S., Mest, H.-J.
Über die Wirksamkeit von Trapidil und einigen Trapidil-
derivaten auf substanzinduzierte Herzarrhythmien an Ratte
und Meerschweinchen
Arzneimittelforsch./Drug Res. 37, 923-926 (1987)
88. Mentz, P., Pawelski, K.E., Orlova, Z.R., Gießler, Ch.,
Mest, H.-J.
Zur Wirksamkeit von Trapidil und einigen Derivaten auf die
Herzfunktion unter In-vitro- und In-vivo-Bedingungen
Pharmazie 42, 403-406 (1987)
89. Mest, H.-J., Schneider, S., Riedel, A.
Relevance of eicosanoids for biochemical regulation of
cardiac rhythm disturbances
Biomed. Biochim. Acta 46, 534-538 (1987)
90. Pönicke, K., Sternitzky, R., Mest, H.-J.
Stimulation of aggregation and thromboxane A2 formation of
human platelets by hypoxia
Prostaglandins Leukotrienes Med. 29, 49-59 (1987)
91. Mentz, P., Pawelski, K.E., Giessler, Ch., Mest, H.-J.
Thromboxan A2-antagonistische Wirkungen von antianginösen
Pharmaka unter besonderer Berücksichtigung von Trapidil und
Trapidil-Derivaten
Pharmazie 42, 613-616 (1987)
92. Riedel, A., Braquet, P., Mest, H.-J.
The effect of the specific PAF antagonist BN 52021 and the
calcium blocker diltiazem on PAF induced arrhythmogenicity
Pharmacol. Res. Comm. 19, 703-712 (1987)
93. Kahl, P.-E., Schimke, E., Hildebrandt, R., Beitz, J.,
Schimke, J., Beitz, A., Mrochen, H., Mest, H.-J.
The influence of cod-liver oil diet on various lipid meta-
bolism parameters, the thromboxane formation capacity,
platelet function and the serum MDA level in patients
suffering from myocardial infarction
Cor Vasa 3, 199-208 (1987)
94. Hoffmann, P., Mest, H.-J.
What about the effects of dietary lipids on endogeneous
prostanoid synthesis?: A state-of-the art review
Biomed. Biochim. Acta 46, 639-650 (1987)
95. Beitz, J., Mest, H.-J.
(n-3) PUFA rich diets modulate the PGI2 inhibitory potency
of low density lipoprotein (LDL) taken from venous blood of
volunteers
Agents Actions 22, 375-376 (1987)
96. Heinroth-Hoffmann, I., Hauser, A., Mest, H.-J.
Inhibition of thromboxane A2 production by trapidil and
trapidil derivatives in the arachidonic acid-injected rat
Prostaglanins Leukotrienes Med. 30, 87-92 (1987)
97. Riedel, A., Mest, H.-J.
PAF induced cardiac arrhythmogenicity and possibilities
for antagonism
J. Moll. Cell. Cardiol. 19, Suppl. 3, 79 (1987)
98. Block, H.-U., Sziegoleit, W., Müller, G., Mest, H.-J.
Experimental variables affecting thromboxane B2 formation
during clotting of human blood
AsiaPacific J. Pharmacol. 2, 223-228 (1987)
99. Mest, H.-J., Block, H.-U.
Prostaglandine und kardiovaskuläres System
Med. aktuell 13, 359 (1987)
100. Mest, H.-J., Riedel, A., Schneider, S.
Relevance of eicosanoids for cardiac rhythm disturbances
J. Mol. Cell. Cardiol. 19, Suppl. 3, 60 (1987)
101. Pissarek, M., Goos, H., Nöhring, J., Graff, H.J.,
Buller, G., Beyerdörfer, I., Mest, H.-J.,
Lindenau, K.-F., Krause, E.-G.
Prostacyclin and iloprost: Equal efficiency in preserving
high energy phosphates in the dog heart following coronary
artery ligation
Basic Res. Cardiol. 82, 566-575 (1987)
102. Wachsmuth, Ch., Langkopf, B., Rebmann, U., Heinemann, H.,
Schabel, J., Pauer, H.-D., Hoffmann, P., Mest, H.-J.
Die Gefäßreaktivität isoliert perfundierter Rattennieren
nach Iloprostkonditionierung der Spenderniere
Probl. Hämatol. Transfus. Transplant. 14, 313-320 (1987)
103. Block, H.-U., Hoffmann-Heinroth, I., Taube, Ch,
Niebisch, M., Mest, H.-J.
Inhibition of thromboxane B2 formation of blood platelets
by trapidil and other s-triazolo (1.5-a)pyrimidine deriva-
tives
Prostaglandins Leukotrienes Med. 30, 77-86 (1987)
104. Beitz, J., Schollberg, K., Fischer, S., Jaross, W., Hane-
feld, M., Mest, H.-J.
Is the level of steroid hormones in the low density lipo-
protein (LDL) particles responsible for the prostaglandin
I2 inhibitory potency of LDL?
Biomed. Biochim. Acta 47, 181-187 (1988)
105. Ernst, A., Taube, Ch., Lotz, P., Mest, H.-J.
Dazoxiben-induced changes in the thromboxane/prostacyclin
balance in the lateral cochlear wall of the guinea pig
Arch. Otorhinolaryngol. 245, 50-52 (1988)
106. Köpernik, H., Mest, H.-J., Schwarz, B.
Pharmakologische Beeinflussung drohender plazentaler In-
suffizienz
Z. Klin. Med. 43, 161-164 (1988)
107. Riedel, A., Schneider,S., Mest, H.-J.
Trapidil on experimental cardiac arrhythmias and possible
side effects
Wiss. Z. Martin-Luther-Univ. Halle-Wittenberg, 37, 39
(1988)
108. Ernst, A., Lotz,P., Taube,CH., Steinborn, Ch., Loebe, L.-P.
The influence of UK 37.248, a TX-synthase inhibitor, on
the eicosanoid distribution in cochlear lateral wall
Wiss. Beitr. Martin-Luther-Univ. Halle-Wittenberg,
(R 104) 27-29 (1988)
109. Ernst, A., Lotz, P., Taube, Ch., Mest, H.-J.
PGI2/TXA2 balance in guinea pig perilymph
Wiss. Beitr. Martin-Luther-Univ. Halle-Wittenberg,
(R 104), 30-32 (1988)
110. Mest, H.-J., Riedel, A., Meyer, E.
PAF antagonists and thromboxane (TX) antagonists abolish
PAF-induced cardiac rhythm disturbances
Prostaglandins 35, 807 (1988)
111. Riedel, A., Desselberger, R., Mest, H.-J.
Cloprostenol prevents reperfusion induced fibrillation in
isolated Langendorff heart preparation of guinea pigs
Biomed. Biochim. Acta 47, 443-444 (1988)
112. Riedel, A., Stern, S., Mest, H.-J.
Veränderte Toxizität von Strophanthin und Akonitin unter
dem Einfluß von Substanzen, die in den Arachidonsäure-
Metabolismus eingreifen
Wiss. Beitr. Martin-Luther-Univ. Halle-Wittenberg,
(R 150), 15-21 (1988)
113. Köpernik, H., Mest, H.-J., Schwarz, B.
Pharmacological management of an impending placental in-
sufficiency
Prostaglandins Leukotrienes Essential Fatty Acids 33,
179-183 (1988)
114. Ernst, A., Taube, Ch., Lotz, P., Mest, H.-J.
The thromboxane/prostacyclin balance in guinea pig
cochlea.
In: Auditory Pathway - Structure and Function ,
eds. I. Syka, B. Masterton, Plenum Press New York,
35-38 (1988)
115. Mentz, P., Mest, H.-J., Anger, H.
Interaction of iloprost and indomethacin with the cardiac
effects of isoprenaline, ouabain and trapidil
Biomed. Biochim. Acta 47, S 109-S 112 (1988)
116. Pissarek, M., Gründer, W., Keller, T., Goos, H.,
Mest, H.-J.
Action of iloprost and PGE2 on global ischemic and
reperfused myocardium: A 31P-NMR-study
Biomed. Biochim. Acta 47, S 121-S 124 (1988)
117. Block, H.-U., Dunemann, A., Niebisch, M., Mest, H.-J.
Influence of the antianginal drug trapidil and its deriva-
tive AR 12463 on arachidonic acid liberation and throm-
boxane formation in thrombin-stimulated platelets
Biomed. Biochim. Acta 47, S 141-S 144 (1988)
118. Heinroth-Hoffmann, I., Hauser, A., Taube, Ch., Mest, H.-J.
Effects of trapidil and trapidil derivatives on
arachidonic acid and prostaglandin endoperoxide analogue
U 46619-induced blood pressure changes in rats
Biomed. Biochim. Acta 47, S 145-S 148 (1988)
119. Beitz, A., Taube, Ch., Beitz, J., Goos, H., Graff, J.,
Nöhring , J., Lindenau, K.-F., Mest, H.-J.
Influence of drugs on the TXA /PGI2 balance and on the
atherogenic index in myocardial ischemia in dogs
Biomed. Biochim. Acta 47, S 149-S 152 (1988)
120. Beitz, J., Corsini, A., Granata, A., Fumagalli, R., Mest,
H.-J., Paoletti, R.
Effect of derivatives of trapidil on the expression of LDL
receptors
Biomed. Biochim. Acta 47, S 153-S 156 (1988)
121. Mest, H.-J., Riedel, A., Braquet, P., Meyer, E.
The arrhythmogenic effect of platelet activating factor
(PAF) is inhibited by PAF antagonist and by substances in-
fluencing eicosanoids
Biomed. Biochim. Acta 47, S 219-S 223 (1988)
122. Fahr, A., Langer, R., Sziegoleit, W., Albert, H.,
Liebal, H., Mest, H.-J.
Influence of pentoxifylline administered in vivo on the
synthesis of PGI2 in human varicose veins
Biomed. Biochim. Acta 47, S 238-S 240 (1988)
123. Mentz, P., Pawelski, K.E., Gießler, Ch., Mest, H.-J.,
Mannes, F., Rotzoll, S.
Myocardial biosynthesis of prostacyclin and the influence
of cardiac loading and drugs
Biomed. Biochim. Acta 47, S 244-S 247 (1988)
124. Köhler, A.H., Köhler, A.R., Taube, Ch., Mest, H.-J.
Decrease in arterial blood pressure in spontaneously hyper-
tensive rats by the TXA2 receptor antagonist BM 13177 and by
acetylsalicylic acid
Biomed. Biochim. Acta 47, S 269-S 273 (1988)
125. Bartels, Th., Hein, W., Taube, Ch., Runge, H., Mest, H.-J.
Correlations between endogenous prostaglandin E formation
in the bone and spongiosa density
Biomed. Biochim. Acta 47, S 278-S 281 (1988)
126. Riedel, A., Schneider, S., Mest, H.-J.
The effect of substances influencing the arachidonic acid
cascade on experimental cardiac arrhythmias
Biomed. Biochim. Acta 47, S 27-S 30 (1988)
127. Mentz, P., Pawelski, K.E., Gießler, Ch., Mest, H.-J.,
Schwab, M., Kersten, T., Czeslick, E.
Significance of the cardioprotective effect of prostanoids
and indomethacin
Biomed. Biochim. Acta 47, S 48-S 51 (1988)
128. Taube, Ch., Martin, S., Köhler, A.H., Köhler, A.R.,
Mest, H.-J.
Influence of acetylsalicylic acid and BM 13177 on blood
pressure and efficacy of antihypertensive drugs in
spontaneously hypertensive rats
Biomed. Biochim. Acta 47, S 94-S 99 (1988)
129. Bartels, Th., Hein, W., Runge, H., Taube, Ch., Hein, G.,
Mest, H.-J.
Einfluß des Linolsäuregehaltes der Nahrung auf
Spongiosadichte und Prostaglandin-Biosynthese im Knochen
Beitr. Orthop. Traumatol. 35, 353-359 (1988)
130. Hein, W., Bartels, Th., Neumann, W., Köhler, St.,
Taube, Ch., Mest, H.-J.
Allogenes Knochenmaterial und resorbierbare Keramiken
tierexperimentelle Studie und erste klinische Erfahrungen
in: Knorpel-Knochentransplantation, ed. H. Hackenbrock,
Stuttgart, Thieme, 132-134 (1988)
Stuttgart, Thieme, 132-134 (1988)
131. Block, H.-U., Gabbasov, Z.A., Polzin, E.Y., Popov, E.G.,
Mest, H.-J.
Inhibition of cytosolic Ca++ mobilization in human platelets
by the antianginal drug trapidil and its derivatives
AR 12463
Biomed. Biochim. Acta 47, 1093-1097 (1988)
132. Beitz, J., Kuklinski, B., Beitz, A., Taube, Ch., Riedel, A.,
Szymanski, Ch., Rath, F.W., Mest, H.-J.
Influence of a HDL rich fraction of human blood in the pro-
stanoid formation, serum and tissue lipids and development
of arteriosclerosis in different systems
Adv. in Lipoprotein and Atherosclerosis Res., Diagn. and
Treatment: Proc. of the 6th Int. Dresden Lipid Symp., Vol.2
478-481 (1988)
133. Mest, H.-J., Beitz, J., Riedel, A., Kuklinski, B.
Is HDL involved in the biochemical regulation of cardiac
rhythm?
Adv. in Lipoprotein and Atherosclerosis Res., Diagn. and
Treatment: Proc. of the 6th Int. Dresden Lipid Symp., Vol. 2
534-536 (1988)
134. Bartels, Th., Runge, H., Taube, Ch., Mest, H.-J.
Zusammenhänge zwischen Linolsäuregehalt der Nahrung,
Spongiosadichte und Prostaglandinbiosynthese im Knochen
Beitr. Orthop. Traumatol. 35, 567 (1988)
135. Schulze, J., Hanefeld, M., Jaroß, W., Beichler, H., Schimke,
E., Mest, H.-J.
Parameter des Lipoproteinstoffwechsels und Thromboxan B2 bei
Hyperlipoproteinämie - (HPL) - Patienten unter ölsupplemen-
tierter Kurorttherapie
Adv. in Lipoprotein an Atherosclerosis Res., Diagn. and
Treatment: Proc. of the 6th Int. Dresden Lipid Sympos.,
Vol.2, 490-493 (1988)
136. Hoffmann, P., Mest, H.-J., Krause, E.-G., Will-Shahab, L.
Investigations on the mechanisms of a diminished inotropic
isoprenaline effect in isolated rat hearts after high lino-
leic acid diet
Biomed. Biochim. Acta 47, 881-886 (1988)
137. Mest, H.-J.
Pharmakologische Untersuchungen zu neu entwickelten
Trapidilderivaten
Wiss. Z. Ernst-Moritz-Arndt-Univ. Greifswald 37,
47-50 (1988)
138. Quauck, St., Mentz, P., Heims, J., Gießler, Ch.,
Mest, H.-J., Barth, A.
Zur Beeinflussung der Dipeptidylpeptidase IV-Aktivität durch
antianginöse Pharmaka sowie durch Trapidil und Trapidil-
derivate
Wiss. Z. Ernst-Moritz-Arndt-Univ. Greifswald 37,
57-58 (1988)
139. Mentz, G., Mentz, P., Mest, H.-J.
Effekte kardiotoner Pharmaka im Vergleich mit zwei Trapidil-
derivativen an hypoxisch und arrhythmogen geschädigten iso-
lierten Herzpräparaten des Meerschweinchens
Wiss. Z. Ernst-Moritz-Arndt-Univ. Greifswald 37,
66-68 (1988)
140. Pawelski, K.-E., Mentz, P., Gießler, Ch., Mest, H.-J.
Zur Wirkung von Trapidil und ausgewählten Herz-Kreislauf-
Pharmaka bei mechanischer und hypoxischer Belastung des
Herzens
Wiss. Z. Ernst-Moritz-Arndt-Univ. Greifswald 37,
69-71 (1988)
141. Beitz, A., Taube, Ch., Beitz, J., Goos, H., Graff, J.,
Pissarek, M., Nöhring, J., Mest, H.-J.
Einfluß von Pharmaka auf Eikosanoidbildung und Lipidspiegel
am Koronarokklusionsmodell des Hundes
Wiss. Z. Ernst-Moritz-Arndt-Univ. Greifswald 37,
85-87 (1988)
142. Scholz, J., Böhme, C., Hoffmann, P., Mest, H.-J.
Einfluß des Linolsäuregehaltes der Nahrung auf kardiovas-
kuläre Katecholaminwirkungen an der narkotisierten Ratte
Wiss. Z. Ernst-Moritz-Arndt-Univ. Greifswald 37,
88-89 (1988)
143. Riedel, A., Schneider, S., Mest, H.-J.
Einfluß verschiedener Pharmaka auf die Eikosanoidbalance
und deren Darstellung durch experimentelle Arrhythmien
Wiss. Z. Ernst-Moritz-Arndt-Univ. Greifswald 37,
90-91 (1988)
144. Wachsmuth, Ch., Langkopf, B., Rebmann, U., Heynemann, H.,
Schabel, J., Pauer, H.-D., Hoffmann, P., Mest, H.-J.
Einfluß einer Iloprostvorbehandlung auf die Gefäßreaktivität
isoliert perfundierter Rattennieren
Wiss. Z. Ernst-Moritz-Arndt-Univ. Greifswald 37,
92-94 (1988)
145. Wachsmuth, Ch., Langkopf, B., Rebmann, U., Heynemann, H.,
Schabel, J., Pauer, H.-D., Hoffmann, P., Mest, H.-J.
Veränderungen ausgewählter Parameter während einer Ilo-
prostinfusion an der narkotisierten Ratte
Wiss. Z. Ernst-Moritz-Arndt-Univ. Greifswald 37,
95-97 (1988)
146. Bartels, Th., Hein, W., Taube, Ch., Mest, H.-J.
Stoffwechselveränderungen in der Spongiosa des Femurs bei
Hüftendoprothesenersatz
Beitr. Orthop. Traumatol. 35, 564 (1988)
147. Bartels, Th., Hein, W., Taube, Ch., Berger, G., Mest, H.-J.
Bedeutung von Ilmaplant als Knochenersatzwerkstoff unter
Berücksichtigung der Prostaglandinbiosynthese im Knochen
Beitr. Orthop. Traumatol. 36, 207-213 (1989)
148. Beitz, A., Taube, Ch., Beitz, J., Goos, H., Graff, J., Nöh-
ring, J., Lindenau, K.-F., Mest, H.-J.
Influence of iloprost on eicosanoid generation and lipid
levels in experimental myocardias ischemia in dogs
Prostaglandins Leukotrienes Essential Fatty Acids 35,
141-146 (1989)
149. Beitz, J., Kuklinski, B., Taube, Ch., Mest, H.-J.
Influence of a plasma fraction of human blood, rich high
density lipoprotein, on in vitro formation of prostaglan-
din I2 (PGI2) and thromboxane A2 (TXA2)
Prostaglandins Leukotrienes Essential Fatty Acids 35,
37-39 (1989)
150. Ernst, A., Syka, J., Mest, H.-J.
Arachidonate metabolites change furosemide-induced cochlear
potentials
Hearing Res. 40, 39-44 (1989)
151. Mentz, P., Mest, H.-J.
Bedeutung endogener Substanzen
Med. aktuell 15, 30-31 (1989)
152. Mest, H.-J., Riedel, A., Meyer, E., Heinroth-Hoffmann, I.,
Mentz, G., Mentz, P., Tschorn, W., Sperling, J.
The relevance of eicosanoids including PAF for the bioche-
mical regulation of cardiac rhythm
In: Prostaglandins in clinical research: cardiovascular
system, ed. K. Schrör, H. Sinzinger, New York, Liss 475-479
(1989)
153. Schrott, A., Egg, G., Lichtenberger, O., Ernst, A.,
Mest, H.-J.
The time-course of furosemide-induced strial changes in
guinea pigs after pretreatment with daltroban
Hearing Res. 42, 17-22 (1989)
154. Corsini, A., Beitz, J., Granata, A., Fumagalli, R., Mest,
H.-J., Paoletti, R.
Trapidil derivatives and low density lipoprotein metabolism
by human skin fibroblasts and by human hepatoma cell line
HEP G2
Pharmacol. Res. 5, 521-531 (1989)
155. Ernst, A., Syka, J., Riedel, A., Mest, H.-J.
Local effects of PAF in guinea-pig inner ear
J. Lipid Mediators 1, 297 - 301 (1989)
156. Weiss, M., Sziegoleit, W., Pönicke, K., Schobess, M., Fahr,
A., Mest, H.-J.
Bioavailability of trapidil tablets
Arzneimittelforsch./Drug Res. 39, 1137-1138 (1989)
157. Ernst, A., Syka, J., Riedel, A., Mest, H.-J.
The effect of PAF in the cochlea of guinea pigs
Prostaglandins 38, 523-529 (1989)
158. Mest, H.-J.
Arzneimittelinteraktionen und mögliche Wechselwirkungen zu
Nahrungs- und Genußmitteln
Recipe, H. 6, 2-5 (1989)
159. Ernst, A., Syka, J., Riedel, A., Mest, H.-J.
The effect of PAF and BN 52021 on inner ear potentials
In: Ginkgolides - Chemistry, Biology, Pharmacology and
Clinical Perspectives, Vol. 2., ed. P. Braquet, 797-803
(1989)
Clinical Perspectives, Vol. 2., ed. P. Braquet, 797-803
(1989)
160. Riedel, A., Meyer, E., Heinroth-Hoffmann, I., Mentz, P.,
Mentz, G., Mest, H.-J.
BN 52021 abolishes PAF-induced cardiac rhythm disturbances
In: Ginkgolides - Chemistry, Biology, Pharmacology and
Clinical Perspectives, Vol. 2., ed. P. Braquet, 275-289
(1989)
Clinical Perspectives, Vol. 2., ed. P. Braquet, 275-289
(1989)
161. Sternitzky, R., Atkov, O.J., Rogoza, A.N., Mest, H.-J.,
Mikhailova, N.V., Pönicke, K., Hänsgen, K., Nilius, R.
Investigations on the role of blood rheology in hypertension
Clin. Haemorheol. 9 (1989) 527
162. Bartels, T., Hein, W., Taube, C., Mest, H.-J.
Prostaglandins-local regulators in bone?
Beitrag zur Orthopadie und Traumatologie 36,(8) 345-9, (1989)
163. Beitz, A., Nikitina, N.A., Giessler, Ch., Beitz, J., Masaev,
V.P., Perova, N.A., Mest, H.-J.
Modulation of TXA2 generation of platelets by human lipo-
proteins
Prostaglandins Leukotrienes Essential Fatty Acids 40,
57-61 (1990)
164. Ernst, A., Mest, H.-J., Egg, G., Schrott, A.
The effects of locally applied PAF in inner ear morphology
J. Lipid Mediators 2, 33-40 (1990)
165. Heinroth-Hoffmann, I., Krüger, J., Tertov, V.V., Orekhov,
A.N., Mest, H.-J.
Influence of trapidil and trapidil derivatives on the
content of cyclic nucleotides in human intima cells cultured
from atherosclerotic plaques
Drug Dev. Res. 19, 321-327 (1990)
166. Beitz, J., Kuklinski, B., Beitz, A., Taube, Ch., Oswald, B.,
Szymanski, Ch., Rath, F.-W., Mest, H.-J.
Influence of high density lipoprotein (HDL), prepared from
human blood, on prostanoid formation, serum and tissue
Szymanski, Ch., Rath, F.-W., Mest, H.-J.
Influence of high density lipoprotein (HDL), prepared from
human blood, on prostanoid formation, serum and tissue
lipids and development of arteriosclerosis in cholesterol
rich fed rabbits
Prostaglandins Leukotrienes Essential Fatty Acids 40,
211-215 (1990)
Prostaglandins Leukotrienes Essential Fatty Acids 40,
211-215 (1990)
167. Sziegoleit, W., Block, H.-U., Modersohn, D., Parsi, R.A.,
Parsi, E., Mest, H.-J.
Wirkung von Heparin und Heparin plus Trapidil auf die
Serumkonzentration von Thromboxan B2 bei Patienten mit
Angina pectoris
Z. Klin. Med. 45, 997-999 (1990)
Parsi, E., Mest, H.-J.
Wirkung von Heparin und Heparin plus Trapidil auf die
Serumkonzentration von Thromboxan B2 bei Patienten mit
Angina pectoris
Z. Klin. Med. 45, 997-999 (1990)
168. Mest, H.-J., Rein, T., Hörhold, I., Riedel, A., Broquet, C.,
Braquet, P.
Anaphylaxis-induced changes in heart rhythm and the
Braquet, P.
Anaphylaxis-induced changes in heart rhythm and the
influence of different mediator antagonists
J. Lipid Mediators 2, 220 (1990)
J. Lipid Mediators 2, 220 (1990)
169. Mest, H.-J., Rein, T., Hörhold, I., Riedel, A.
Mediators are involved in anaphylaxis-induced arrhythmoge-
nicity
J. Mol. Cell. Cardiol. 22, Suppl. 3, 69 (1990)
Mediators are involved in anaphylaxis-induced arrhythmoge-
nicity
J. Mol. Cell. Cardiol. 22, Suppl. 3, 69 (1990)
170. Steinborn, Ch., Taube, Ch., Mest, H.-J.
Verteilungskoeffizienten von Trapidilderivaten und ihre
Korrelation zur "molecular connectivity"
Pharmazie 45, 370-371 (1990)
Verteilungskoeffizienten von Trapidilderivaten und ihre
Korrelation zur "molecular connectivity"
Pharmazie 45, 370-371 (1990)
171. Beitz, J., Mest, H.-J.
Polyungesättigte Fettsäuren und Eikosanoide (COX-Weg)
Sitzungsberichte der AdW der DDR, 10-15 (1990)
Polyungesättigte Fettsäuren und Eikosanoide (COX-Weg)
Sitzungsberichte der AdW der DDR, 10-15 (1990)
172. Macholz, R., Wagenknecht, C., Martin, S., Wirth, M., Moritz,
V., Mest, H.-J., Taube, Ch., Engst, W., Leopold, F.,
Petrzika, M., Knoll, R., Rödel, W., Przybilski, H.
Beiträge zur gesundheitlichen Bewertung ungeradzahliger
V., Mest, H.-J., Taube, Ch., Engst, W., Leopold, F.,
Petrzika, M., Knoll, R., Rödel, W., Przybilski, H.
Beiträge zur gesundheitlichen Bewertung ungeradzahliger
Fettsäuren
Sitzungsberichte der AdW der DDR, 23-33 (1990)
Sitzungsberichte der AdW der DDR, 23-33 (1990)
Akademie-Verlag Berlin
173. Bartels, Th., Beitz, J., Hein, W., Schumann, M., Laag, L.,
Beitz, A., Szymanski, Ch., Mest, H.-J.
Veränderungen der Spongiosadichte im Femurkopf des Kanin-
chens bei Atherosklerose
Beitr. Orthop. Traumatol. 37, 291-297 (1990)
Beitz, A., Szymanski, Ch., Mest, H.-J.
Veränderungen der Spongiosadichte im Femurkopf des Kanin-
chens bei Atherosklerose
Beitr. Orthop. Traumatol. 37, 291-297 (1990)
174. Zipprich, B., Gerhardt, C., Giessler, Ch., Taube, Ch., Rath,
F.-W., Mest, H.-J., Nilius, R.
Prostazyklin- und Thromboxansynthese im Lebergewebe bei
chronischen Lebererkrankungen
Z. med. Lab.diagn. 31, 299-304 (1990)
Prostazyklin- und Thromboxansynthese im Lebergewebe bei
chronischen Lebererkrankungen
Z. med. Lab.diagn. 31, 299-304 (1990)
175. Klinger, W., Mest, H.-J., Rein, H.
Im Mittelpunkt des Interesses: Endotheline, Cytochrom P 450
und Antineoplastone
10. Kongreß der Polnischen Pharmakologischen Gesellschaft,
Bialystok, 1989
Medizin aktuell 16, 428 (1990)
176. Mest, H.-J., Rein, T., Riedel, A.
Antagonists of PAF and histamine inhibit ouabain-induced
cardiac arrhythmias in sensitized guinea-pigs
Pol. J. Pharmacol. Pharm., 42, 283-289 (1990)
177. Mest, H.-J., Riedel, A., Rein, T.
WEB 2086, a novel specific PAF antagonist, prevents PAF
induced arrhythmogenicity
Pharmacol. Res. 22, 445-453 (1990)
176. Mest, H.-J., Rein, T., Riedel, A.
Antagonists of PAF and histamine inhibit ouabain-induced
cardiac arrhythmias in sensitized guinea-pigs
Pol. J. Pharmacol. Pharm., 42, 283-289 (1990)
177. Mest, H.-J., Riedel, A., Rein, T.
WEB 2086, a novel specific PAF antagonist, prevents PAF
induced arrhythmogenicity
Pharmacol. Res. 22, 445-453 (1990)
178. Heinroth-Hoffmann, I., Hauser, A., Mest, H.-J.
Effects of platelet activating factor antagonists on
arachidonic acid-induced platelet aggregation and TXA2
formation
Prostaglandins Leukotrienes and Essential Fatty Acids 41,
181-182 (1990)
179. Beitz, A., Nikitina, N., Giessler, Ch., Beitz, J.,, Masaev,
Effects of platelet activating factor antagonists on
arachidonic acid-induced platelet aggregation and TXA2
formation
Prostaglandins Leukotrienes and Essential Fatty Acids 41,
181-182 (1990)
179. Beitz, A., Nikitina, N., Giessler, Ch., Beitz, J.,, Masaev,
V.P., Perov, N.A., Mest, H.-J.
Modulation of TXA2 generation of platelets by human lipopro-
teins
Naunyn-Schmiedeberg's Arch. Pharmacol. 342 (Suppl.), R2
Modulation of TXA2 generation of platelets by human lipopro-
teins
Naunyn-Schmiedeberg's Arch. Pharmacol. 342 (Suppl.), R2
(1990)
180. Beitz, J., Corsini, A., Bellosta, S., Bernini, F.,
180. Beitz, J., Corsini, A., Bellosta, S., Bernini, F.,
Fumagalli, R., Mest, H.-J., Paoletti, R.
Influence of trapidil and derivatives on the cholesterol
synthesis and esterification in cultured cells
Naunyn-Schmiedeberg's Arch. Pharmacol. 342 (Suppl.), R3
(1990)
181. Block, H.-U., Markau, S., Mest, H.-J.
Phosphodiesterase inhibitors reduce arachidonic acid release
and thromboxane formation in thrombin-stimulated human
platelets
Naunyn-Schmiedeberg's Arch. Pharmacol. 342 (Suppl.), R5
(1990)
182. Heinroth-Hoffmann, I., Block, H.-U., Hagen, A., Mest, H.-J.
Antiplatelet effect of the new cardiotonic agent IWF 122-14
compared to milrinone and amrinone
Naunyn-Schmiedeberg's Arch. Pharmacol. 342 (Suppl.), R13
(1990)
Influence of trapidil and derivatives on the cholesterol
synthesis and esterification in cultured cells
Naunyn-Schmiedeberg's Arch. Pharmacol. 342 (Suppl.), R3
(1990)
181. Block, H.-U., Markau, S., Mest, H.-J.
Phosphodiesterase inhibitors reduce arachidonic acid release
and thromboxane formation in thrombin-stimulated human
platelets
Naunyn-Schmiedeberg's Arch. Pharmacol. 342 (Suppl.), R5
(1990)
182. Heinroth-Hoffmann, I., Block, H.-U., Hagen, A., Mest, H.-J.
Antiplatelet effect of the new cardiotonic agent IWF 122-14
compared to milrinone and amrinone
Naunyn-Schmiedeberg's Arch. Pharmacol. 342 (Suppl.), R13
(1990)
183. Heinroth-Hoffmann, I., Hauser, A., Mest, H.-J.
Effects of platelet activating factor antagonists on
arachidonic acid induced platelet aggregation and thrombo-
xane A2 formation
Naunyn-Schmiedeberg's Arch. Pharmacol. 342 (Suppl.), R14
(1990)
184. Mest, H.-J., Hörhold, I., Rein, T.
Anaphylaxis-induced changes in the threshold dose of
ouabain-induced cardiac arrhythmia are inhibited by
mediator antagonists
Naunyn-Schmiedeberg's Arch. Pharmacol. 342 (Suppl.), R26
(1990)
Naunyn-Schmiedeberg's Arch. Pharmacol. 342 (Suppl.), R26
(1990)
185. Taube, Ch., Hoff, U. Köhler, A., Martin, S., Schirner, M.,
Steinborn, Ch., Mest, H.-J.
Sexual dimorphism of blood pressure in response to acetyl
salicylic acid and to vasoactive substances
Naunyn-Schmiedeberg's Arch. Pharmacol. 342 (Suppl.), R160
(1990)
Steinborn, Ch., Mest, H.-J.
Sexual dimorphism of blood pressure in response to acetyl
salicylic acid and to vasoactive substances
Naunyn-Schmiedeberg's Arch. Pharmacol. 342 (Suppl.), R160
(1990)
186. Mest, H.-J.
Trapidil: a potent inhibitor of platelet aggregation
J. Drug Dev. 3; 143-149 (1990)
187. Block, H.-U., Markau, S., Mest, H.-J.
Phosphodiesterase inhibitors reduce arachidonic acid release
and thromboxane formation in thrombin-stimulated human
platelets
Thromb. Haemorrh. Disorders 2: 83-85 (1990)
188. Bartels, Th., Lueddeckens, G., Hein, W., Förster, W., Taube,
Ch., Pfeiffer, M., Pfeiffer, A., Mest, H.-J.
Beeinflussung von Lipoxygenaseprodukten im Knochen durch den
Linolsäuregehalt der Nahrung
Z. exp. Chir. Transplant. künstl. Organe 23, 171-174 (1990)
189. Corsini, A., Beitz, J., Bellosta, S., Bernini, F.,
Fumagalli, R., Mest, H.-J., Paoletti, R.
Effect of trapidil and its derivatives on the receptor-medi-
ated low density lipoprotein metabolism by cultures human
hepatic and extrahepatic cells
Atherosclerosis and cardiovascular disease, (eds. by G.C.
Descovich, A. Gaddi, G.L. Magri and S. Lenzi), Kluwer
Academic Publishers Dordrecht/Boston/London, 468-476, (1990)
190. Forth,H.-J., Rebmann,U., Heynemann,H., Schabel,J., Pauer,H.-D.,
Mehlhorn,G., Scharf,R., Mest,H.-J.
Examination for improvement of the ischemic tolerance of the kidney by the prostacyclin analogue iloprost
Zeitschrift für Experimentelle Chirurgie Transplantation und Künstliche Organe 23 (2) 79-82 (1990)
191. Struck, H.G., Mest, H.-J., Giessler, Ch., Mentz, P.,
Schäfer, K.
Untersuchungen zur Anwesenheit und Konzentration von zyklo-
oxygenaseabhängigen Entzündungsmediatoren im Kammerwasser
während der Kataraktextraktion
4. Kongreß der Deutschen Gesellsch. für Intraokularlinsen
für Implantation/Springer Verlag Berlin, Heidelberg, 83-88
(1991)
192. Sziegoleit, W., Block, H.-U., Fahr, A., Mest, H.-J.
Serum thromboxane B2 after intravenous administration of
talinolol and propranolol in healthy subjects
Pharmazie 46, 58 (1991)
193. Beitz, A., Beitz, J., Giessler, Ch., Kuklinski, B., Müller,
G, Mest, H.-J.
High density lipoprotein from different species inhibits the
thromboxane A2 generation capacity of platelets from
clotting whole blood
Deutsche Gesellschaft für Pharmakologie und Toxikologie,
Naunyn-Schmiedeberg`s Arch. Pharmacol. 343 (Suppl.), R44,
(1991)
194. Beitz, J., Krüger, J., Beitz, A., Pawelski, K., Szymanski,
Ch., Rath, F.W., Mest, H.-J.
Influence of the trapidil derivative AR 12463 on serum and
tissue lipids and development of aortic lesions during ex-
perimental atherosclerosis in rabbits
Biomed. Biochim. Acta 50, 101-107 (1991)
195. Beitz, J., Riedel, A., Beitz, A., Giessler, Ch., Kittel, A.
Mest, H.-J.
The trapidil derivative AR 12456 protects against serum
hyperlipidemia in guinea pigs
Journal of Lipid Mediators 3, 177-186 (1991)
196. Sziegoleit, W., Wichmann Th., Block, H.-U., Taube, Ch.,
Mest, H.-J.
Thromboxan B2 und Prostaglandin F2a im Serum bei familiärer
kombinierter Hyperlipoproteinämie und familiärer Hyper-
cholesterolämie
Wien Klin Wochenschr 103/8, 227-231 (1991)
197. Struck, H.G., Geiser, H., Taube, Ch., Block, H.-U., Mest,
H.-J., Tost, M.
Zur antiphlogistischen Wirksamkeit des Ginkgolids BN 52021
bei der Verätzung des Kaninchenauges
Klin. Mbl. Augenheilk. 199, 278-282 (1991)
198. Mest, H.-J., Herold, A., Rein, T., Hörhold, I.
Effects of mediator antagonists on ischemia- and ouabain-
induced cardiac arrhythmias in sensitized and non-sensitized
guinea-pigs
J. Mol. Cell. Cardiol. 23, S.92 (1991)
199. Abbas, N.A., Taube, Ch., Hirschelmann, R., Mest, H.-J.
Thromboxane plasma level in kappa-carrageenin-induced
acronecrosis of the tail in rats
Biomed. Biochim. Acta 7, 937-941 (1991)
200. Mest, H.-J., Balewska, I.
Alpha- but not beta-receptor blocking agents inhibit the
antiarrhythmic effect of iloprost on ouabain-induced
arrhythmia in guinea-pigs
Biomed. Biochim. Acta 7, 943-947 (1991)
201. Beitz, J., Corsini, A., Bellosta, S., Bernini, F.,
Fumagalli, R., Mest, H.-J., Paoletti, R.
Influence of trapidil and derivatives on cholesterol
synthesis and esterification in cultured cells
Pharmacol. Res. 3, 235-242 (1991)
202. Struck, H.G., Giessler, Ch., Erfurt, I., Mentz, P., Mest,
H.-J., Tost, M.
Zum Einfluß nichtsteroidaler Antiphlogistika auf das
Vorkommen von Entzündungsmediatoren im Kammerwasser während der Kataraktextraktion
In M. Wenzel, M. Reim, H. Freyler, Ch. Hartmann: 5. Kongreß
der Deutschsprachigen Gesellschaft für Intraokularlinsen-
Implantation. 647-652, Springer, Berlin-Heidelberg (1991)
203. Struck, H.G., Geiser, H., Block, H.-U., Mest, H.-J.,
Tost, M.
Leukotriene antagonist S 872419 A for early-phase treatment
of chemical burn in the rabbit eye
Europ. J. of Ophthalmol. 3, 137-141 (1991)
204. Kircheis, G., Prietzsch, P., Böhme, I., Gieseler, C., Mest,
H.-J.,Nilius, R.
Prostaglandin E1 and tocopherol induced changes of
thromboxan A2 (TXA2) in acute injury
J. of Hepatology 2, R145 (1991)
205. Beitz, J., Mest, H.-J.
A new derivative of trapidil (AR 12456) as a potentially new
antiatherosclerotic drug
Cardiovasc. Drug Rev. 9, 385-397 (1991)
206. Mest, H.-J., Hörhold, I, Rein, T., Riedel, A., Broquet, C.
Effect of BN 52256 and other mediator antagonists on ouabain-
induced cardiac arryhthmia in a model of anaphylaxis in guinea-pigs
Eicosanoids 4, 41 (1991)
207. Fahr, A., Langer, R., Sziegoleit, W., Blauschmidt, J., Albert, H., Liebal, H., Mest, H.-J.
207. Fahr, A., Langer, R., Sziegoleit, W., Blauschmidt, J., Albert, H., Liebal, H., Mest, H.-J.
Verapamil and the systhesis of prostacyclin in human veins.
Pharmazie 46 (3): 213-4, (1991)
208. Mest, H.-J., Hörhold, I., Rein, T., Riedel, A., Broquet, C.
Effect of BN 52256 and other mediator antagonists on
ouabain-induced cardiac arrhythmia in a model of anaphylaxis
in guinea-pigs
Pharmacol. Res. 25, 173-180 (1992)
209. Kircheis,G., Wolter,T., Rath,F.W., Gieseler,C., Mest,H.-J., Boehme,I.,
Nilius,R.
Effects of PGE-1 and PGE-2 on hepatic Antioxidant Enzymes ABD Histological changes following chronic liver injury
Journal of Hepatology 16 (Suppl.1) 97 (1992)
210. Kircheis,G., Wolter,T., Rath,F.W., Gieseler,C., Mest,H.-J., Boehme,I.,
Nilius,R.
Effects of PGE-1 and PGE-2 on hepatic Antioxidant Enzymes ABD Histological changes following chronic liver injury
Journal of Hepatology 16 (Suppl.1) 42 (1992)
211. Ernst, A., Syka, J., Mest, H.-J.
Electrophysiological responses of the cochlea to transient
asphyxia are influenced by arachidonate metabolites
Prostaglandins 43, 331-338 (1992)
212. Beitz, J., Beitz, A., Müller, G., Giessler, Ch., Mest, H.-J.
Influence of HDL on the formation of 6-keto-PGF1_ and TXB2
in vitro: the importance of the source of HDL
Eicosanoids 5, 53-56 (1992)
213. Beitz, J., Beitz, A., Giessler, Ch., Mentz, P., Orekhov,
A.N., Andreeva, E.R., Mest, H.-J.
Influence of a cholesterol rich diet in rabbits on the for-
mation of PGI2 and TXA2
Prostaglandins in the Cardiovascular System; Birkhäuser
Verlag Basel, 235-241 (1992)
214. Mest, H.-J., Rein, T., Riedel, A., Köpernick, W.,
Broquet, C.
Effect of BN 52256 and other mediator antagonists on ouabain
induced ventricular fibrillation in sensitized guinea-pigs
and on ischemia-induced fibrillation in rats
Prostaglandins in the Cardiovascular System; Birkhäuser
Verlag Basel, 228-234 (1992)
215. Heinroth-Hoffmann, I., Giessler, C., Mest, H.-J.
Relevance of vasoactive mediators for the blood pressure
effects of intravenous arachidonic acid injection in rats
Prostaglandins Leukotrienes and Essential Fatty Acid 46,
197-201 (1992)
216. Mentz, P., Mentz, G., Giessler, C., Mest, H.-J.
Interactions of prostanoids with the platelet activating
factors
Prostaglandins Leukotrienes and Essential Fatty Acids 47,
13-16 (1992)
217. Mest, H.-J., Künzelmann, G.
Thromboxan antagonist BM 13.177 and lox-inhibitor VZ 65
protect anaphylaxis-mediated arrhythmogenicity
J. Mol. Cell. Cardiol. 24, 30 (1992)
218. Beitz,J., Beitz,A., Antonov,I.V., Misharin, A.Y., Mest, H.-J.
Does a HDL injection reduce the development of
serum hyperlipidemia and progression of fatty
streaks in cholesterol fed rabbits ?
Prostaglandins,Leukotrienes and Essential Fatty
Acids 47, 149-152 (1992)
219. Mest,H.-J., Rein,T., Riedel,A., Kopernik,W., Broquet,C.
Effect of BN52256 and other mediator antagonists on ouabain-
induced ventrical fibrillation in sensitized guinea pigs and on
ischemia-induced fibrillation in rats
Agents-Actions-Suppl.; 37:228-34 (1992)
220. Pönicke,K., Hoffmann-Heinroth,I., Giessler,C., Mest,H.-J.
The importance of histamine, thromboxane and prostacyclin to contraction and arrhythmia of anaphylactic guinea-pig heart-influence of drugs
Naunyn-Schmiedeberg's Arch. Pharmacol. 347 (Suppl.), R84 (1993)
221. Mest,H.-J., Hoffmann-Heinroth,I., Pönicke,K., Gießler,C.
Bedeutung der Freisetzung von Histamin, Thromboxan und Prostazyklin für Kontraktion und Arrhythmien bei anaphylaktischen Herzen - Einfluß des 5-Lipoxygenasehemmers VZ65
in: "Entzündung und verwandte Reaktionen neue Erkenntnisse neue Wirkstoffe", ed. Hirschelmann, R., Meissner Druckhaus GmbH, 1993, S.183-191.
222. Corsini,A., Grignaffini,P., Beitz,J., Mest,H.-J., Bellosta,S., Fumagalli,R.
Effect of Trapidil Derivative AR 12456 on Intracellular Cholesterol Homeostasis in Human Hepatoma Cell Line Hep G2
Cytotechnology 11: S15-17, 1993
223. Ernsberger,P., Elliott,H.L., Weimann,H.-J., Raap,A., Haxhiu,M.A., Hofferber,E., Löw-Kröger,A., Reid,J.L.,
Mest,H.-J.
Moxonidine: A Second-generation Central Antihypertensiv Agent
Cardiovascular Drug Reviews, 1993, Vol.11, No.4, pp.411-431
224. Beitz, A., Perova, N., Nikitina, N., Beitz, J., Scherbakova, I., Giessler, C., Mest, H.-J.
Lipoptoteins from normolipididemic and dyslipidemic subjects modify the thromboxans A2 gernation by platelets in
clotting human blood.
Prostaglandins Leukotrienes & Essential Fatty Acids 48 (6)
475-9 (1993)
225. Beitz,J., Beitz,A.; Misharin,A.Y., Pawleski,K.-E., Mest,H.-J.
Does HDL injection reduce the development of serum hyperlipidemia and progression of fatty streaks in cholesterol fed rabbits?
Athletes 71, 164 (1993)
226. Mest,H.-J.
Eicosanoide in "Veterinärmedizinische Endokrinologie"
Hrsg. Döcke,F., Gustav Fischer Verlag Jena, 1994, S.672-690
227. Mest,H.-J., Pönicke,K., Heinroth-Hoffmann,I., Meißner,N.,
Gießler,Ch.
The Relevance of Histamine, Eicosanoids and Catecholamines to Contraction, Coronary Perfusion Pressure and Cardiac Arrhythmia of Isolated Anaphylactic Guinea-Pig-Heart
Naunyn-Schmiedeberg's Arch.Pharmacol.349 (Suppl.),R32 (1994)
228. Raap,A., Grott,W., Mest,H.-J., Blechacz,W.
Cardiovascular Effects of the Inotropic Agent BDF 9148 and its Enantiomers in Dogs
Naunyn Schmiedeberg's Arch.Pharmacol.349 (Suppl.),R60 (1994)
229. Mest,H.-J., Raap,A., Thomsen,P.
The Antiarrhythmic Effect of Selective I1-Imidazoline Receptor (SIR) Agonist Moxonidine on Ouabain-induced Arrhythmia in Guinea-pig.
Can.J.Phys.Pharm. 72(Suppl.1), 85 (1994)
230. Raap,A., Grott,W., Mest,H.-J., Blechacz,W.
Cardiovascular effects of the inotropic agent, BDF 9148, and its enantiomers in dogs.
Can.J.Phys.Pharm. 72(Suppl.1), 100 (1994)
231. Beitz,A., Beitz,J., Mest,H.-J.
Is the antiatherosclerotic potency of HDL modulated by the origin of HDL?
Prostaglandins Leukotrienes & Essential Fatty Acids 50 (3) 115-121 (1994)
232. Mest,H.-J., Pönicke,K., Heinroth-Hoffmann,I., Meißner,N.
and Gießler,Ch.
Relevance of Mediators to Cardiac Parameters of Isolated Anaphylactic Guinea-Pig Heart.
Prostaglandins Leukotrienes and Essential Fatty Acids 53, 21-29 (1995)
233. Mest,H.-J., Raap,A., Rosch,A., Thomsen,P.
I1-Imidazoline Receptor Modulating Substances Influence Ouabain-induced Cardiac Arrhythmia.
Pharmacol.Res. 31(Suppl.)27(1995)
234. Mest,H.-J., Raap,A., Rosch,A., Thomsen,P.
The Antiarrhythmic Effect of I1-Imidazoline Receptor Modulator Moxonidine on Experimentally-Induced Cardiac Arrhythmia (CA)
Nauny-Schmiedeberg’s Arch Pharmacol, 351 (Suppl.) R108 (1995)
Frühjahrstagung der DGPT, 14.-16.März 1995 in Mainz
235. Raap,A., Mest,H.-J., Armah,B., Grott,W., & Blechacz,W.
BDF 9198, A New Na+-Channel Activating Inotropic Agent with Higher in Vitro and In Vivo Potency as BDF 9148 and DPI 201-106
Naunyn-Schmiedeberg’s Arch Pharmacol, 351 (Suppl.) R103 (1995)
Frühjahrstagung der DGPT, 14.-16. März 1995 in Mainz
236. Raap,A., Mest,H.-J., Armah,B., Grott,W., & Blechacz,W.
BDF 9198, A New Na+-Channel Activating Inotropic Agent with Higher in Vitro and In Vivo Potency as BDF 9148 and DPI 201-106
Journal of Molecular and Cellular Cardiology (1995)
Xvth World Congress of the ISHR, July 2-7, 1995 in Prag
237. Raap,A., Armah,B., Mest,H.-J., Stenzel,W., and Blechacz,W.
BDF 9198, ein neuer Na+Kanal-Aktivator mit höherer Potenz als BDF 9148 und DPI 201-106: in vitro und in vivo Untersuchungen.
Z.Kardiol., 84 (Suppl.1) 238 (1995)
238. Mest,H.-J., Thomsen,P., and Raap,A.
Antiarrhythmic Effect of the Selective I1-Imidazoline Receptor Modulator Moxonidine on Ouabain-Induced Cardiac Arrhythmia in Guinea Pigs.
The Annals of the New York Academy of Sciences, Vol 763,
620-633 (1995)
239. Schafer, S.G., Kaan, E.C., Christen, M.O., Low-Kröger, A., Mest, H.-J., Molderings, G.J.
Why imidazoline receptor moxonidine on ouabain-induced cardiac arrhythmia in guinea pigs.
Annals of the New York Academy of Sciences 763: 620-33
(1995)
240. Wahls,K., and Mest, H.-J. Mest
Relevance of incubation time and Glucose Concentration for
Insulin Release from Mouse Pancreatic Islets
Naunyn-Schmiedeberg´s Arch Pharmacol, 354 (Suppl.1), R 13 (1996)
Herbsttagung der DGPT, 10.-12.September 1996 in Dresden
241. Hamann,M., Steckel,B. and H.-J. Mest
Studies of the Glucose-Sensitivity of the Insulin-Secreting
Cell-Line BTC6,F7
Naunyn-Schmiedeberg´s Arch Pharmacol. 354, (Suppl.1),
R 13 (1996)
Herbsttagung der DGPT, 10.-12. September 1996 in Dresden
242. B.Steckel, M.Hamann, and H.-J.Mest
Effects of Imidazoline Compounds on an Insulin-Secreting
Cell Line - BTC6,F7 - and functional Studies
Naunyn-Schmideberg´s Arch Pharmacol. 354, (Suppl.1), R 14 (1996)
Herbsttagung der DGPT, 10.-12. September 1996 in Dresden
243. R.Macharzina, T.Heitzer, T.Eleftheriadis, E.Schroeder,
H.-J.Mest, T. Münzel, T., T.Meinertz
Vaskulär Dysfunktion und gesteigerte Superoxidproduktion in Aorten von cardiomyopathischen Syrischen Hamstern(CSH)
Zeitschrift f. Kardiologie 86 (2) 194 (1997)
244. R.Macharzina, T.Heitzer, A.Groth, H.-J.Mest, T.Münzel,
T.Meinertz
Gesteigerte kardiale und renale Superoxidproduktion in
Cardiomyopathischen Syrischen Hamstern (CSH)
Zeitschrift f. Kardiolgie 86 (2) 74 (1997)
245. M.F.O´Neill, M.W.Conway, U.Giese, H.-J.Mest, W.Blechacz
Lack of effect of selective imidazoline I2 ligands forced swim test in mice.
British Journal of Phamacology 122, 168P (1997)
246. E.M.A.Mervaala, L.Malmberg, T.-L.Teräväinen, T.Lähteenmäki,
K.K.H.Paakari, I.Pörsti, H.-J.Mest, H.Vapaatalo, H.Karppanen
Influence of different dietary salts on the cardiovascular and renal effects of moxonidine in spontaneously hypertensive rats
Naunyn-Schmiedebergs Arch. Pharmacol 356: 107-114 (1997)
247. M.Hamann, B.Steckel, H.-J.Mest
Glucose Dependent Insulin Secretion by the Adenylate
Cyclase (AC) / cAMP-System in the Insulinoma Cell Line
bTC6,F7.
Diabetologica 40: (Suppl.1), A113 (440), 1997
248. K.Wahls, H.-J.Mest
Insulin Release Depends on Glucose Concentration, Incuba-
tion Time, Temperature, and PH Tested in Mouse and Rat
Islets
Diabetologica 40: (Suppl.1), A113 (437), 1997
249. J.Schloos, B.Steckel, A.Raap, M.R.Jirousek, G.Gold, H.-J.
Mest
The Imidazoline RX871024 and the Secretion GLP-1 Induce
Glucose Dependent Insulin Secretion in bTC-6 Cells
Diabetologica 40: (Suppl.1), A105 (407), 1997
250. A.Raap, B.Armah, H.-J.Mest, W.Stenzel, J.Schloos,
W.Blachacz
Investigations of the mechanism of the positive action of BDF 9148;
Comparison with DPI 201-106 and the enantiomers.
J Cardiovac Pharmacol 29: 164-173,1997
251. A.Raap, J.Schloos, B.Steckel-Hamann, H.-J.Mest
Effects pf GLP-1 and Midaglizole at eu-and Hyperglycemia in a modified IV Glucose Tolerance Test in Anesthetized Rats
34th Annual Meeting of the EASD, Barcelona, Sept. 8-12, 1998
Diabetologica 41: (Suppl.1), A137 (532), 1998
252. I.B.Efanova, S.V.Zaitsev, A.M.Efanov, C.-G.Östenson, A.Raap,
H.-J.Mest, P.-O.Berggren, S.Efendic
Effects of Imidazoline Derivative RX871024 on Insulin, Glucagon, and Somatostatin Secretion from Isolated Perfused Rat Pancreas
Biochemical and Biophysical Research Communications 252: 162-165 (1998)
253. M.I.Steinberg, E.McCall, H.-J.Mest, A.Raap, T.Wright
Cardiac Sodium Channels as Targets for New Inotropic Agents
Heart Failure Reviews 2: 173-193 (1998)
254. A.Raap, H.-J.Mest, J.Schloos, J. Scheel, P. Thomsen,
W.Grott, B.Steckel-Hamann
A Modified Intravenous Glucose Tolerance Test in Anesthetized Wistar Rats
Archives of Pharmacology 357, 4 R 83 (Suppl.) 1998
255. K.Louchami, A.Laghmich, H.Jijakli, H.-J.Mest, W.J.Malaisse
Secretory, Biosynthetic and Cationic Responses to 2-(N-Phenyl-Indoyl) Imidazole in Rat Pancreatic Islets
Pharmacological Research 38, 305-310, 1998
256. B.Möbius, U.Giese, H.-J.Mest
The Relevance of Phosphodiesterase (PDE) Inhibitors on Insulin Release of ßTC6, F7 Cells
Archives of Pharmacology 359: (Suppl.), R81 (309), 1999
257. A.Willbrandt, H.-J.Mest
Investigations on Endothelium-Dependent Relaxation Aorta During Development of Stz-Induced Diabetes Mellitus Rats
Archives of Pharmacology 359: (Suppl.), R81 (310), 1999
258. S.V.Zaitsev, A.M.Efanov, A.Raap, I.B.Efanova, J.Schloos,
B.Steckel-Hamann, O.Larsson, C.-G.Östenson, P.-O.Berggren, H.-J.Mest, S.Efendic
Different Modes of Action of the Imidazoline Compound RX871024 in Pancreatic ß-Cells
Annals of the New York Academy of Sciences 881:, 241-252, 1999
259. M.J.Fisher, A.E.Arfstan, U.Giese, B.P.Gunn, C.S.Harms, V.Khau, M.D.Kinnick, T.D.Lindstrom, M.J.Martinelli, H.-J.Mest, M.Mohr, J.M.Morin, Jr.J.T.Mullaney, A.Nunes, M.Paal, A.Raap, G.Rühter, K.J.Ruterbories, D.J.Sall, R.M.Scarborough, T.Schotten, B.Sommer, W.Stenzel, R.D.Towner, S.L.Um, B.G.Utterback, R.T.Vasileff, S.Vöelkers, V.L.Wyss, J.A.Jakubowski
Fused Bicyclic Gly-Asp ß-Turn Mimics with Specific Affinity for GPIIb-IIIa
Journal of Medicinal Chemistry 42:, (23) 4875-4889, 1999
260. H.-J.Mest
Glucose-Induced Insulin Secretion by Imidazolines
Fundam.Clin.Pharmacol. 14: (Nr.1), 65, 2000
261. C.Brunn, J.Schloos, S.Sewing, P.Lemansky, S.Wawro, H.-J.Mest
Characterization of Musarinic Receptor Subtypes on the GLUTag Mouse Enteroendocrine Cell Linie
Diabetologia 42 (Supp.1), A 199, 1999
262. C.Brunn, J.Schloos, P.Lemansky, S.Sewing, H.-J.Mest
Insulin as a Feedback Regulator of Glucagon-Like Peptide-1 (GLP-1) Release?
British Journal of Pharmacology 128, 107P, 1999
263. M.J.Fisher, U.Giese, C.S.Harms, M.D.Kinnick, T.D.Lindstrom, J.R.McCowan, H.-J.Mest, J.M.Morin, J.T.Mullaney, M.Paal, A.Raap, G.Rühter, K.J.Ruterbories, D.J.Sall, R.M.Scarbotough, T.Schotten, W.Stenzel, R.D.Towner, S.L.Um, B.G.Utterback, V.L.Wyss, J.A.Jakubowski
Fused Bicyclic Gly-Asp ß-Turn Mimics with Potent Affinity for GPIIb-IIIa. Exploration of the Arginine Isostere
Bioorganic & Medicinal Chemistry Letters 10, 385-389, 2000
264. A.Raap, V.Koivisto, U.Giese, H.-J.Mest
A New Imidazoline Compound Improves Insulin Secretion and Glucose Homeostasis in Zucker Diabetic Fatty Rats
Diabetologia 43, Suppl.1, A-125, 2000
Abstracts of the 36th Annual Meeting of the EASD Jerusalem, Israel, 17-21 Sept. 2000
265. H.-J.Mest, A.Raap, J.Schloos, I.Treinies, M.Paal, U.Giese,
V.Koivisto
A Novel Treatment for Type 2 Diabetes: A Glucose-Induced Insulin Secretion by Imidazolines
Diabetologia 43, Suppl.1, A-125, 2000
Abstracts of the 36th Annual Meeting of the EASD Jerusalem, Israel, 17-21 Sept. 2000
266. A.M.Efanov, S.V.Zaitsev, P.-O.Berggren, H.-J.Mest, S.Efendic
Imdidazoline RX871024 Raises Diacylglycerol Levels in Rat Pancreatic Islets
Biochemical and Biophysical Research Communications 281, 1070-1073, 2001
267. A.M.Efanov, S.V.Zaitsev, H.-J.Mest, A.Raap, I.B.Appelskog,
O.Appelskog., O.Larsson, P.-O.Berggren, S.Efendic
The Novel Imidazoline Compound BL 11282 Poentiates Glucose-Induced Insulin Secretion in Pancreatic ß-Cells in the Absence of Modulation of KATP Channel Activity
Diabetes50, 797-802, 2001
268. H.-J.Mest, A.Raap, J.Schloos, I.Treinies, M.Paal, U.Giese,
V.Koivisto
Glucose-induced insulin secretion is potentiated by a new imidazolinecompound
Naunyn-Schmiedeberg´s Arch Pharmacol 364, 47-52, 2001
269. A.M.Efanov, I.B.Appelskog, S.M.Abdel-Halim, A.Khan, R.Bränström, O.Larsson, C.-G.Östenson, H.-J.Mest, P.-O.Berggren, S.Efendic, S.V.Zaitsev
Insulinotropic activity of the imidazoline derivative RX871024 in the diabetic GK rat
Am J. Physiol.Endocrinol Metab 282, E117-E124, 2002
270. M.Scheltdorf, H.-J.Mest
Pertussis toxin converts hyperpolarizations caused by a2-adrenoceptor
Agonists containin g an imidazoline moiety into depolarizations in
MIN 6 cells
Naunyn-Schmiedeberg´s Arch Pharmacol 366, 204-208, 2002
271. P.Proks, I.Treinies, H.-J.Mest, S.Trapp
Inhibition of recombinant KATP channels by the antidiabetic agents
Midaglizole, LY 397364 and LY 389382
European Journal of Pharmacology 452, 11-19, 2002
272. M.B.Brenner, H.-J.Mest
The Novel Imidazoline Compound LY 374284 Restores first Phase of Insulin Secretion in Islets from db/db Mice
Diabetologia 46,
Ystad, Sweden, 28-31 August 2002
273. M.B.Brenner, J.Gromada, A.M.Efanov, K.Bokvust, H.-J.Mest
Restoration of First-Phawe Insulin Secretion by the Imidazoline Compound LY 374284 in Pancreatic Islets of Diabetic db/db Mice
Ann.N.Y.Acad.Sci. 1009, 332-340, 2003
274. H.-J.Mest
Both the imidazoline compound LY374284 and GLP-1 have been shown to enhance insuline secretion in islets of db/db mice, whereas the sulfonylurea tolbutamide fails (T15)
Fourth International Symposium on Agmatine and
Imidazoline Systems, San Diego, 9-11 April 2003
275. I.Treinies, S.Sewing, A.Raap, A.Delaunois, O.Depelchin, J.J.Holst, J.Gromada, H.-J.Mest, E.Sher
AMPA receptor isoforms 2 and 3 mediate the stimulatory action of LY451646 on insulin and glucagon secretion in rats
Diabetologia 46, 472, 2003
276. M.Brenner, A.Raap, H.-J.Mest
Perifused islets of thiazolidinedione pretreated db/db mice show enhanced insulin secretion
Diabetologia 46, 512, 2003
277. M.B.Brenner, J.Gromada, A.M.Efanov, K.Bokvist, H.-J.Mest
Restoration of First-Phase Insulin Secretion by the Imidazoline Compound LY 374284 in Pancreatic Islets of Diabetic db/db Mice
Ann.N.Y.Acad.Sci. 1009, 332-340, 2003
278. M.B.Brenner, H.-J.Mest
The Imidazoline Compound LY374284 Shows GLP-1 like characteristics in two different animal Models of Type 2 diabetes
Naunyn-Schmiedeberg´s Arch Pharmacology 369, R71, 2004
279. B.Evers, D.Barrett, J.A.Dodge, L.N.Jungheim, H.-J.Mest, E.-M.Martin de la Nava, B.S.Muehl, S.Petersen, G.Rühter, M.J.Tebbe, K.J.Thrasher
Substituted Dipeptide Compounds as Growth Hormone Secretagogues; Synthesis and Selected SAR of the Dipeptide Domain
Drugs of the Future 29 (Suppl.A) 340, 2004
280. H.-J.Mest, R.Mentlein
Dipeptidyl peptidase inhibitors as new drugs fort he treatment of type 2 diabetes
Diabetologia 48 (2005) 616-620
281. Evers,B., Ruehter,G., Berg,M., Dodge,J.A., Hankotius,D., Hary,U., Jungheim,L.N., Mest,H.-J., Martin De la Nava,E.- M., Mohr,M., Muehl,B.S., Petersen,S., Sommer,B., Riedel- Herold,G., Tebbe,M.J., Thrasher,K.J., Voelkers,S.
Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues
Bioorganic & Medicinal Chemistry letters 13 (2005) 6748-6762
282. Mest,H.-J.
DPIV inhibitors can restore glucose homeostasis in type 2 diabetics via incretin enhancement
Current Opinion in Investigational Drugs 7 (2006) 336-343
283. Sheehan, S.M., Mest,H.-J., Watson,B.M., Klimkowski,V.J.,
Timm,D.E., Couvin,A., Parsons,S.H., Shi, Q., Canada,E.J.,
Wiley,M.R., Ruehther, G., Evers,B., Peterson,S., Blaszczak,
L.C., Pulley,S.R., Margolis,B.J., Wishart,G.N., Renson,G.,
Hankotius,D., Mohr,M., Zechel,J.C., Kalbfleisch,M.J.,
Dingess-Hammond,E.A., Boelke,A., Weichert,A.G.
Discovery of non-covalent dipeptidyl peptidase IV inhibitors
Which induce a conformational change in the active site
Bioorganic & Medicinal Chemistry letters 17 (2007) 1765
Februar 2006